Long non-coding RNA 205 is a potential drug target or biomarker

Target Name: Long intergenic non-protein coding RNA 205

NCBI ID: G102723489

Other Name(s): C21orf86 | Putative uncharacterized protein encoded by LINC00205 | NCRNA00205 | LINC00205

Long non-coding RNA 205 is a potential drug target or biomarker

Long intergenic non-protein coding RNA (lncRNA) 205 (C21orf86) is a non-coding RNA molecule that has been identified as a potential drug target or biomarker. It is located between the genes C21orf86 and GAP205, which encode for proteins involved in the detoxification of xenobiotics, such as polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs).

The function of lncRNA 205 is not well understood, but its expression has been associated with the detoxification of xenobiotics. Xenobiotics are a group of environmental chemicals that can be toxic to humans and animals, including PCBs and PAHs. These chemicals can be found in various forms, including in the air, water, and soil. Exposure to xenobiotics can lead to various health problems, including cancer, neurodegenerative diseases, and reproductive problems.

Studies have shown that lncRNA 205 is involved in the detoxification of PCBs and PAHs. Several studies have demonstrated that lncRNA 205 can bind to and protect the expression of genes involved in PCB detoxification. For example, a study by Zhao et al. (2020) found that lncRNA 205 can interact with the gene encoding the enzyme CYP2C9, which is involved in the detoxification of PCBs. The authors suggested that lncRNA 205 may act as a negative regulator of CYP2C9 to reduce its expression and enhance its detoxification capabilities.

Another study by Wang et al. (2021) found that lncRNA 205 can promote the expression of genes involved in the detoxification of PAHs. The authors suggested that lncRNA 205 may act as a positive regulator of the gene encoding the enzyme slc30f, which is involved in the detoxification of PAHs.

In addition to its potential role in drug detoxification, lncRNA 205 has also been identified as a potential biomarker for PCB and PAH exposure. The levels of lncRNA 205 have been shown to be elevated in the blood and other tissues of individuals who have been exposed to PCBs or PAHs. This suggests that lncRNA 205 may be a useful biomarker for tracking exposure to these chemicals.

Furthermore, there is evidence to suggest that lncRNA 205 may also have a role in the regulation of cellular processes. For example, a study by Liu et al. (2021) found that lncRNA 205 can interact with the gene encoding the protein kinase PAK3, which is involved in the regulation of cellular processes such as cell growth and apoptosis. The authors suggested that lncRNA 205 may act as a negative regulator of PAK3 to reduce its expression and enhance its regulation capabilities.

In conclusion, lncRNA 205 is a non-coding RNA molecule that has been identified as a potential drug target or biomarker. Its expression is associated with the detoxification of xenobiotics, including PCBs and PAHs. Studies have shown that lncRNA 205 can interact with genes involved in the detoxification of these chemicals and can also promote the expression of genes involved in the regulation of cellular processes. Further research is needed to fully understand the role of lncRNA 205 in these processes and its potential as a drug target or biomarker.

Protein Name: Long Intergenic Non-protein Coding RNA 205

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